The effect of partial host immunity on the transmission of malaria parasites.

Transmission Dynamics of Malaria in Human Host: a Neuro-Fuzzy Approach

Effects of Cryptolepine, 2, 7, dibromocryptolepine and standard drugs on hemoglobin accumulation in cultured Malaria parasites

Cryptolepine is the major alkaloidal constituent of the West African climbing shrub Cryptolepis sanguinolenta, a species used in traditional medicine for the treatment of malaria and a number of other infectious diseases. Cryptolepine and a number of its synthetic analogues have been shown to have potent antiplasmodial activities using P. falciparum lactate dehydrogenase assay (PfLDH). Intraery...

Carcinogenicity and Anti-tumoral Effect of Parasites: A Review Study

In endemic areas, some parasitic infections may be related to cancer induction or induction of immune responses against cancer. In some cases, parasites cause disease in their host, and in other cases, they reach a biological balance with them. Parasite invasion of the host depends on some factors such as parasite species, life cycle, enzyme production, and host immunity. The results of various...

Immune Escape Strategies of Malaria Parasites

Malaria is one of the most life-threatening infectious diseases worldwide. Immunity to malaria is slow and short-lived despite the repeated parasite exposure in endemic areas. Malaria parasites have evolved refined machinery to evade the immune system based on a range of genetic changes that include allelic variation, biomolecular exposure of proteins, and intracellular replication. All of thes...

Modeling the development of acquired clinical immunity to Plasmodium falciparum malaria.

Individuals living in regions where malaria is endemic develop an acquired immunity to malaria which enables them to remain asymptomatic while still carrying parasites. Field studies indicate that cumulative exposure to a variety of diverse Plasmodium parasites is required for the transition from symptomatic to asymptomatic malaria. This study used a simulation model of the within-host dynamics...